SrasV1, Main, Exploration, bibRecord, 001929

Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus

Identifieur interne : 001929 ( Main/Exploration ); précédent : 001928; suivant : 001930

Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus

Auteurs : Stanley Perlman ; Jincun Zhao

Source :

mBio [ 2150-7511 ] ; 2013.

RBID : PMC:3551544

Descripteurs français

KwdFr :
- Animaux, Attachement viral, Coronavirus (physiologie), Humains, Récepteurs viraux (métabolisme).
MESH :
- métabolisme : Récepteurs viraux.
- physiologie : Coronavirus.
- Animaux, Attachement viral, Humains.

English descriptors

KwdEn :
- Animals, Coronavirus (physiology), Humans, Receptors, Virus (metabolism), Virus Attachment.
MESH :
- chemical , metabolism : Receptors, Virus.
- physiology : Coronavirus.
- Animals, Humans, Virus Attachment.

Abstract

ABSTRACT

A newly identified betacoronavirus, human coronavirus EMC (HCoV-EMC), has been isolated from several patients with respiratory and renal disease in the Middle East. While only a few infected patients have been identified, the mortality of the infection is greater than 50%. Like its better-known cousin severe acute respiratory syndrome coronavirus (SARS-CoV), HCoV-EMC appears to have originated from bats. In a recent article in mBio, Müller et al. described several important differences between the two viruses [M. A. Müller et al., mBio 3(6):e00515-12, 2012, doi:10.1128/mBio.00515-12]. Unlike SARS-CoV, HCoV-EMC can directly infect bat cells. As important, HCoV-EMC does not enter cells using the SARS-CoV receptor, human angiotensin-converting receptor-2 (hACE2). These results provide a strong incentive for identifying the host cell receptor used by HCoV-EMC. Identification of the receptor will provide insight into the pathogenesis of pulmonary and renal disease and may also suggest novel therapeutic interventions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551544

DOI: 10.1128/mBio.00002-13
PubMed: 23322635
PubMed Central: 3551544

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>A newly identified betacoronavirus, human coronavirus EMC (HCoV-EMC), has been isolated from several patients with respiratory and renal disease in the Middle East. While only a few infected patients have been identified, the mortality of the infection is greater than 50%. Like its better-known cousin severe acute respiratory syndrome coronavirus (SARS-CoV), HCoV-EMC appears to have originated from bats. In a recent article in <italic>mBio</italic>
, Müller et al. described several important differences between the two viruses [M. A. Müller et al., <italic>mBio</italic>
 3(6):e00515-12, 2012, doi:10.1128/mBio.00515-12]. Unlike SARS-CoV, HCoV-EMC can directly infect bat cells. As important, HCoV-EMC does not enter cells using the SARS-CoV receptor, human angiotensin-converting receptor-2 (hACE2). These results provide a strong incentive for identifying the host cell receptor used by HCoV-EMC. Identification of the receptor will provide insight into the pathogenesis of pulmonary and renal disease and may also suggest novel therapeutic interventions.</p>
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Serveur d'exploration SRAS

Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus

Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
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